JN403, an alpha-7-nicotine-acetylcholine-receptor agonist, reduces alpha-synuclein induced inflammatory parameters of in vitro microglia but fails to attenuate the reduction of TH positive nigral neurons in a focal alpha-synuclein overexpression mouse model of Parkinson's disease.
Bolam Lee, Carmen Noelker, Dominik Feuerbach, Lars Timmermann, Wei‐Hua Chiu, Wolfgang Hermann Oertel
This study evaluates JN403, a 7-nAChR agonist, showing reduced inflammation in microglia but no neuroprotection in a PD mouse model.
bioRxiv · Apr 4, 2020 · PreprintNeuroscience