PGE2 modulation of stimulus valence directs zebrafish behavioral fever
Bradley Cutler, Claire E Tobin, Hailey L. Hollins, Kaarthik A Balakrishnan, James A. Gagnon, Martin Haesemeyer
This study shows that PGE2 alters temperature stimulus valence in zebrafish, making heating attractive and cooling aversive, challenging the idea that fever reduces perceived warmth.
bioRxiv · May 12, 2026 · PreprintNeuroscience