James A. Gagnon

This study shows that zebrafish larvae rely on zygotic gadusol synthesis in epidermal mucus for UVB protection after maternal gadusol depletion.

The paper shows that ciliates enhance zebrafish virus transmission by concentrating viruses, but not all viruses are transmitted, suggesting selectivity.

The paper tracks clonal dynamics of spermatogonial stem cells in zebrafish over time and finds non-neutral drift patterns inconsistent with random chance.

This study shows that PGE2 alters temperature stimulus valence in zebrafish, making heating attractive and cooling aversive, challenging the idea that fever reduces perceived warmth.

The paper investigates DNA repair dynamics during zebrafish embryogenesis, revealing a transition from fast but error-prone repair to slower, more accurate repair mechanisms.

MIC-Drop-seq combines CRISPR and scRNA-seq to phenotype mutant zebrafish embryos, revealing known and novel gene functions in development.

This study identifies IFNφ1 as a key driver of interferon signaling after zebrafish heart injury, showing its role in promoting early neutrophil recruitment but not macrophage response or neovascularization.

This study compares cardiac injury responses in zebrafish and medaka to identify features distinguishing regenerative and non-regenerative heart responses.

This study uses single-cell RNA sequencing to analyze zebrafish testis development, finding that infertile testes lack mature germ cells and show increased immune cell presence.

The paper shows gadusol, a maternal compound in zebrafish, protects embryos from UV damage by reducing DNA damage markers, and its biosynthesis pathway is conserved in teleosts but lost in species without UV exposure.

This study investigates how zebrafish larvae distinguish self-generated reafferent mechanosensory signals from exafferent stimuli using lateral line hair cells and neural circuits.

The paper demonstrates that multiple CRISPR-Cas systems and anti-CRISPR proteins function in zebrafish embryos, enabling combinatorial genome editing and recording.

This study shows that zebrafish dscaml1 is crucial for retinal patterning and oculomotor circuit function, with mutations causing deficits in gaze stabilization and saccade fatigue similar to human ocular motor apraxia.

ampliCan provides precise quantification and visualization of genome editing events, outperforming existing tools in benchmark tests.

The paper introduces scGESTALT, a method that combines single-cell RNA sequencing with lineage tracking to identify cell types and their developmental relationships in the zebrafish brain.

The study shows zebrafish Nanog is essential for extraembryonic tissue development but not directly required for embryonic cell differentiation.