Heterozygous mutation to Chd8 causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouse
Andrea L Gompers, Linda Su-Feher, Jacob Ellegood, Tyler W Stradleigh, Iva Zdilar, Nycole A Copping, Michael C Pride, Melanie D Schaffler, M Asrafuzzaman Riyadh, Gaurav Kaushik, Brandon Mannion, Ingrid Plajzer-Frick, Veena Afzal, Axel Visel, Len A Pennacchio, , Alex S Nord
This study shows that heterozygous Chd8 mutation in mice causes macrocephaly and widespread transcriptional changes in neurodevelopmental networks, similar to human CHD8 mutations.
bioRxiv · Sep 20, 2016Neuroscience