Linda Su-Feher

Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis

The paper identifies combinatorial TF-cRE interactions in mouse basal ganglia development, revealing modules that drive GABAergic neurogenesis and suppress other fates.

Parallel functional testing identifies enhancers active in early postnatal mouse brain

The paper identifies and validates enhancers active in early postnatal mouse brain using a modified MPRA approach and rAAV delivery.

Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

This study shows that deleting a non-canonical regulatory region of Scn1a in mice leads to reduced Scn1a expression and epileptic symptoms.

Single Cell Enhancer Activity Maps Neuronal Lineages in Embryonic Mouse Basal Ganglia

The paper uses scRNA-seq and enhancer-based labeling to map neuronal lineages in embryonic mouse basal ganglia and identifies novel lineage specification paths.

A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in mice.

This study identifies transcriptomic and neuroanatomical changes in mouse embryos exposed to maternal immune activation, revealing altered neurodevelopmental timing and cortical development.

Heterozygous mutation to Chd8 causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouse

This study shows that heterozygous Chd8 mutation in mice causes macrocephaly and widespread transcriptional changes in neurodevelopmental networks, similar to human CHD8 mutations.