Neurofibromin is essential to maintain metabolic function and sustain life in the adult mouse
Ashley N Turner, Maria S. Johnson, Stephanie Nicole Brosius, Brennan S. Yoder, Kevin Yang, Qinglin Yang, John F. Moore, J. Daniel Sharer, Daniel L. Smith, Tim R. Nagy, Trent R. Schoeb, Bruce R. Korf, Robert A. Kesterson
This study shows that systemic loss of neurofibromin in adult mice causes metabolic dysfunction and death, indicating roles beyond tumor suppression.
bioRxiv · May 17, 2018 · PreprintGenetics