Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: a computational study of gene regulatory pathways using Boolean networks
Aditya Lahiri, Haswanth Vundavilli, Madhurima Mondal, Pranabesh Bhattacharjee, Brian Decker, Giuseppe Del Priore, Norman Peter Reeves, Aniruddha A. Datta
This study uses Boolean networks to identify optimal drug targets in TNBC stem cell pathways, finding that inhibiting STAT3, GLI, and NF-κB can prevent relapse and that drug combinations are more effective.
IEEE Access · Jan 1, 2023Peer-reviewedSystems Biology