Xylazine's k-opioid agonist activity is not shared with other FDA-approved alpha2-adrenergic agonists
Xi-Ping Huang, Brian E Krumm, Madigan L. Bedard, Zoé A. McElligott, Bryan L. Roth
The paper investigates whether other FDA-approved alpha2-adrenergic agonists share xylazine's kappa opioid agonist activity and finds they do not, but have distinct GPCR activity patterns.
bioRxiv · Mar 7, 2026 · PreprintNeuroscience