Madigan L. Bedard

This study investigates how biased signaling at NTSR1 modulates GABAergic transmission in the extended amygdala and affects feeding behavior in mice.

The paper investigates whether other FDA-approved alpha2-adrenergic agonists share xylazine's kappa opioid agonist activity and finds they do not, but have distinct GPCR activity patterns.

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

The paper develops a segmentation protocol for anterior medial temporal lobe regions and integrates it into an automated approach to improve imaging biomarkers for neurodegenerative diseases.

This study shows that xylazine and fentanyl co-administration in mice delays wound healing, while neither drug alone does so at tested doses.

This study shows xylazine enhances fentanyl's interoceptive effects in rats, suggesting it may contribute to the risks of xylazine-adulterated fentanyl.

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

This study shows xylazine acts as a kappa opioid receptor agonist and that naloxone induces withdrawal from xylazine and fentanyl/xylazine combinations, with greater sensitivity in females.

This study examines how different morphine withdrawal paradigms affect sleep behavior in male and female mice, finding sex-specific differences and highlighting the 3-day precipitated withdrawal model as most impactful.

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.