Derivation of Isogenic Mesodermal and Ectomesodermal Chondrocytes from Human Induced Pluripotent Stem Cells for Articular Cartilage Regeneration
Ming‐Song Lee, Matthew J. Stebbins, Hongli Jiao, Hui-Ching Huang, Brian E. Walzack, Sean P. Palecek, Eric V. Shusta, Wan‐Ju Li
This study derives and compares mesodermal and ectomesodermal chondrocytes from hiPSCs, showing that ectomesodermal-derived chondrocytes better resemble native chondrocytes and have improved cartilage repair capabilities.
bioRxiv · Oct 2, 2020 · PreprintDevelopmental Biology