Author

Brian J. Mendoza

Oak Ridge National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Cong T. TrinhiD· 3 shared Caleb Walker· 1 shared David Dooley· 1 shared Sergio GarciaiD· 1 shared Seunghyun RyuiD· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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3 shared papersBioinformatics

Cong T. TrinhORCID

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3 papers

Recent·Most cited

Gene Co-expression Connectivity Predicts Gene Targets Underlying High Ionic Liquid Tolerance in Yarrowia lipolytica

Caleb Walker, Seunghyun Ryu, Sergio Garcia, David Dooley, Brian J. Mendoza, Cong T. Trinh

The paper introduces GeCCo to identify gene targets for high ionic liquid tolerance in Y. lipolytica and finds that GeCCo-selected genes, BRN1 and OYE2, enhance tolerance when overexpressed.

bioRxiv · Mar 17, 2022 · PreprintSystems Biology

In Silico Processing of the Complete CRISPR-Cas Spacer Space for Identification of PAM Sequences

Brian J. Mendoza, Cong T. Trinh

The paper develops a pipeline to identify PAM sequences for CRISPR-Cas systems across bacterial genomes, finding putative PAMs for 1,049 species out of 1,493 analyzed.

Biotechnology Journal · Aug 7, 2018Peer-reviewedBioinformatics

Enhanced Guide-RNA Design And Targeting Analysis For Precise CRISPR Genome Editing Of Single And Consortia Of Industrially Relevant And Non-Model Organisms

Brian J. Mendoza, Cong T. Trinh

The paper introduces CASPER, a CRISPR tool improving on- and off-target prediction and enabling multitargeting and multispecies genome editing in non-model organisms.

Bioinformatics · Sep 7, 2017Peer-reviewedBioinformatics