The nuclear Argonaute HRDE-1 broadly interacts with euchromatin via an RGG domain to enable transgenerational epigenetic silencing
Julie Zhouli Ni, Natasha Mason, Junjie Liu, Meghana Thimmaraju, Brina Trivedi, Joyce Naguib, Joyce Naguib
This study identifies the RGG domain of HRDE-1 as essential for chromatin binding and transgenerational epigenetic silencing in C. elegans, revealing a conserved mechanism for AGO-chromatin interaction.
bioRxiv · Oct 16, 2026 · PreprintMolecular Biology