C. elegans

Structural determinants underlie the essentiality of the m-type thioredoxin TrxA in Synechocystis

The paper identifies structural determinants in TrxA that confer its essentiality in Synechocystis, showing that its function cannot be replaced by other thioredoxins despite similar abundance.

Anisotropic regulation of lateral surface tension directs invagination in C. elegans gastrulation

The paper shows that anisotropic lateral surface tension, mediated by HMR-1/E-cadherin, directs invagination in C. elegans gastrulation, complementing apical constriction.

Cell cycle progression and stalked cell morphogenesis in Caulobacter crescentus are regulated independently by the flagellum

This study identifies fss genes that regulate stalked cell morphogenesis and cell cycle progression independently of the flagellum in Caulobacter crescentus.

Calibrating developmental dynamics from single-cell atlases: lineage paths outrun least-action routes

The paper introduces LADD to measure lineage path deviations from inferred developmental dynamics in single-cell RNA-seq data and finds lineages move faster than optimal paths.

Cisplatin-triggered sensory dysfunction in NER-defective C. elegans involves GABAergic and cholinergic signaling

This study identifies GABAergic and cholinergic signaling disruptions as key mechanisms of cisplatin-induced sensory dysfunction in NER-defective C. elegans.

Starve, stress, and mate: Activation of the CCAAT-Binding complex overrides sterility of mating-type heterozygous Candida albicans

The paper identifies the CCAAT-binding complex (CBC) as a key regulator that overrides genetic sterility in Candida albicans by integrating environmental stress signals to enable mating.

Elevated precontractile calcium set point is sustained by limited PMCA1 export in dystrophic muscle

The paper shows that dystrophic muscle has an elevated precontractile calcium set point sustained by limited PMCA1 export in C. elegans and human myoblasts.

Tools for genetic mapping and gene identification in Caenorhabditis briggsae

The paper updates a toolkit for genetic studies in C. briggsae by identifying indel variants and mapping mutations to genes using high-throughput sequencing.

How mutation rate evolves: Gene expression shapes genome-wide mutation rates in Drosophila melanogaster and Caenorhabditis elegans

The paper investigates how gene expression influences genome-wide mutation rates in Drosophila melanogaster and Caenorhabditis elegans, finding that highly expressed genes have lower mutation rates due to transcription-coupled repair.

Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo

This study uses advanced microscopy to show that myosin II minifilaments persist and recycle in C. elegans embryos, contributing to cortical contractility through stable, static interactions with actin.

The enemy of my enemy: A bacterial antagonist rescues Chlamydomonas by inactivating a toxin from a rival

The paper shows that Pseudomonas fluorescens protects Chlamydomonas reinhardtii from Pseudomonas protegens by inactivating its toxin protegencin in a tripartite microbial interaction.

Monounsaturated fatty acid depletion is a metabolic pattern of pathogenesis surveilled to activate p38 MAPK innate immunity

The paper identifies oleate depletion as a metabolic signal sensed by C. elegans to activate innate immunity against bacterial infection.

The C. elegans Connectome Toolbox: an open, extensible framework for multimodal connectomic data integration and analysis

The paper introduces the C. elegans Connectome Toolbox, a framework for integrating and analyzing multimodal connectomic data, enabling comparison across datasets and modalities.

Variation in the embryonic cell lineages of Caenorhabditis elegans natural populations

The paper quantifies developmental variation in C. elegans natural populations using embGAN, finding genotype-specific differences in cell-cycle timing that exceed within-strain variation.

Temperature alters Culex tarsalis West Nile virus vector competence, tissue bottlenecks, and transcriptional responses

This study shows that temperature affects Culex tarsalis vector competence, tissue bottlenecks, and gene expression in response to West Nile virus infection.

Nematode species differ in susceptibility and response to the nematode-trapping fungus Arthrobotrys oligospora

This study compares the susceptibility and molecular responses of three nematode species to the nematode-trapping fungus Arthrobotrys oligospora, revealing species-specific differences in behavior and gene expression.

Orsay virus infection is associated with reduced locomotion and alters cue-dependent food choice in Caenorhabditis elegans

This study shows Orsay virus infection reduces locomotion in C. elegans and alters food choice based on sensory context, with eol-1 modulating these behaviors.

Systematic comparison of genetically encoded F-actin probes for visualizing actomyosin dynamics in vivo using C. elegans

The paper compares three F-actin probes in C. elegans, finding mStayGold offers best brightness and photostability, while mNeonGreen is suitable for photobleaching applications.

The Application of 3D Cryo-Volume Electron Microscopy to Visualize and Quantify the Photosynthetic Filamentous Cyanobacterium Anabaena

This paper uses cryo-vEM to visualize and quantify ultrastructural features of two Anabaena species without chemical pre-treatment.

Connectome structure constrains neural activity across scales

The paper shows that coarse-grained connectome partitions can preserve functional predictions about neural activity even when path structure is lost.

ALIGN: A modular framework for quantitative analysis of longitudinal development in Caenorhabditis elegans

ALIGN provides a modular framework for analyzing longitudinal development in C. elegans, enabling accurate segmentation, quality control, and motion correction across imaging conditions.

Developing synthetic auxin-based trans-kingdom signaling

This paper develops a tunable auxin-based trans-kingdom signaling system that enables cross-species communication by engineering auxin biosynthesis and response mechanisms in different organisms.

CrJAMs are transcriptional repressors of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

This study identifies CrJAM2 and CrJAM3 as transcriptional repressors of the MIA pathway in C. roseus, showing their repression is modulated by methyl JA treatment.

Stochastic and Heritable Responses in Cell-Size Regulation and Survival to pH Stress in C. glutamicum

This study examines how C. glutamicum cells respond to pH stress by tracking cell size and survival, revealing stochastic and heritable differences in acid and alkaline stress survival.

Sodium arsenite requires redox sensitization to cause developmental dopaminergic neurotoxicity in Caenorhabditis elegans

This study shows that sodium arsenite requires additional mitochondrial or redox stress to cause dopaminergic neurotoxicity in C. elegans, but not fluoroacetic acid.

Brain-wide representations of olfactory behavior in C. elegans

The paper analyzes brain-wide neural activity in C. elegans during olfactory navigation and identifies functional circuits linking sensory input to motor behavior across different environments and behavioral states.

Classical guinea pig coat phenotypes are associated with variants in FGF5 and CELSR1

This study identifies genetic variants in FGF5 and CELSR1 associated with long and rough coat phenotypes in guinea pigs, revealing distinct molecular mechanisms.

Sensory recurrence and convergent integration in the C. elegans connectome

The paper analyzes the C. elegans connectome to show recurrence and convergence patterns in neural signaling, revealing structural substrates for non-feed-forward signaling.

Therapeutic vulnerabilities of the drug-resistant fungal meningitis pathogen Cryptococcus neoformans

This study identifies therapeutic vulnerabilities in Cryptococcus neoformans using CRISPR-insert and machine learning, revealing new drug targets and synthetic lethal dependencies.

Local fractal dimension as an indicator of functional reorganization in molecular interaction networks

The paper introduces DIFFRACT, a framework that uses local fractal dimension changes in protein interaction networks to detect functional reorganization, showing its utility in identifying novel biological roles in RAVER1-deficient cells.