Life without mismatch repair
Mathijs Arnoud Sanders, Harald S. Vöhringer, Victoria J. Forster, Luiza Moore, Brittany B. Campbell, Yvette E. Hooks, Melissa Edwards, Vanessa Bianchi, Tim H. H. Coorens, Timothy M. Butler, Henry Lee-Six, Philip S. Robinson, Christoffer Flensburg, Rebecca A. Bilardi, Ian J. Majewski, , Peter J. Campbell
The paper quantifies mismatch repair (MMR) activity in human tissues by analyzing mutation rates in individuals with constitutional MMR deficiency, revealing genotype-specific mutational signatures and the role of MMR components in DNA repair.
bioRxiv · Apr 14, 2021 · PreprintGenomics