CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery
Yuxiao Wang, Ruei‐Zeng Lin, Meghan T. Harris, Bianca P. Lavayen, Neha Diwanji, Bruce J. McCreedy, Robert Hofmeister, Daniel R. Getts
The paper introduces CREATE, an RNA-based gene editing system that delivers large genes without DSBs or DNA templates, achieving specific genomic integration in human cells.
EMBO Reports · Jan 9, 2025Peer-reviewedSynthetic Biology