Reprogrammed Serine Integrases Enable Precise Integration of Synthetic DNA
Friedrich Fauser, Sebastian Arangundy‐Franklin, Jessica E. Davis, Lifeng Liu, Nicola J Schmidt, Luis Rodriguez, Danny F. Xia, Nga Nguyen, Nicholas A. Scarlott, Rakshaa Mureli, Irene Tan, Yuanyue Zhou, Lynn N. Truong, Sarah J Hinkley, Bhakti N Kadam, , Jeffrey C. Miller
The paper develops a MINT platform to reprogram serine integrases for precise synthetic DNA integration into specific chromosomal sites in human cells.
bioRxiv · May 9, 2024 · PreprintSynthetic Biology