Beyond Blacklists: A Critical Assessment of Exclusion Set Generation Strategies and Alternative Approaches
Brydon P. G. Wall, Jonathan D. Ogata, Matthew T. Nguyen, Amy L. Olex, Konstantinos V. Floros, Anthony C. Faber, Joseph L. McClay, Joshua Chuck Harrell, Mikhail G. Dozmorov
The paper evaluates exclusion set generation strategies in short-read sequencing, finding that pre-generated Blacklists are hard to reproduce and proposes sponge sequences as an alternative to reduce artifacts.
Bioinformatics · Feb 28, 2026Peer-reviewedBioinformatics