Isomerization of antimalarial drug WR99210 explains its inactivity in a commercial stock
T. P. Remcho, S. D. Guggilapu, P. Cruz, G. A. Nardone, G. Heffernan, R. O'Conner, C. A. Bewley, T. Wellems, K. D. Lane
The paper identifies an isomer of WR99210 that explains its inactivity, showing structural and functional differences between two commercial compounds.
bioRxiv · Jul 1, 2020Biochemistry