Molecular determinants underlying DS2 activity at δ-containing GABAA receptors
C. B. Falk-Petersen, F. Rostrup, R. Loffler, S. Buchleithner, K. Harpsoe, D. Gloriam, B. Frolund, P. Wellendorph
This study identifies the molecular site of action for DS2 at δ-containing GABAA receptors, showing that its selectivity arises from a conserved TMD binding pocket rather than direct δ-subunit interaction.
bioRxiv · Jan 21, 2021 · PreprintPharmacology & Toxicology