Self-assembly of Grb2 meshworks revealed by Grb2-Gab1497-528 complex structure
C. Breithaupt, T. Gruber, K. Mandel, M. Lewitzky, A. Meister, B. Jochen, S. M. Feller, M. T. Stubbs
This paper presents the structure of Grb2 bound to a Gab1 peptide, revealing its ability to form two-dimensional meshworks and phase-separated condensates through SH2/cSH3 domain interactions.
bioRxiv · Jun 17, 2023 · PreprintBiochemistry