Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10
C. Ivaldo, M. Passalacqua, A. L. Furfaro, C. d'Abramo, S. Ruiz, P. K. Chatterjee, C. N. Metz, M. Nitti, P. Marambaud
This study shows oxidative stress induces VE-cadherin proteolysis via MMPs and γ-secretase in HUVECs, with BMP9/10 reducing this effect and protecting against apoptosis.
bioRxiv · Nov 23, 2022 · PreprintCell Biology