The FXR agonist obeticholic acid does not stimulate liver regeneration in hepatectomized mice.
K. M. C. van Mierlo, C. Dahrenmoller, V. Lebrun, P. L. M. Jansen, C. H. C. Dejong, I. A. Leclercq, S. W. M. Olde Damink, F. G. Schaap
This study investigates whether obeticholic acid (OCA) or FGF19 can stimulate liver regeneration after partial hepatectomy in mice, finding no significant effect on liver mass recovery or regenerative indices.
bioRxiv · Nov 10, 2022 · PreprintCell Biology