Modeling Resistance and Recurrence Patterns of Combined Targeted- Chemoradiotherapy Predicts Benefit of Shorter Induction Period
D. M. McClatchy, H. Willers, A. N. Hata, Z. Piotrowska, L. V. Sequist, H. Paganetti, C. Grassberger
The paper develops a bio-mathematical model to simulate recurrence patterns in lung cancer under combined targeted therapy and CRT, showing that long induction periods may reduce the effectiveness of adjuvant therapy.
bioRxiv · Dec 2, 2019Biophysics