The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins
C. Tempra, C. La Rosa, F. Lolicato
This study investigates how alpha-helix structure influences protein-lipid binding in amyloidogenic proteins, showing that helix content affects contact probability and supports a lipid-chaperon model for membrane interaction.
bioRxiv · Nov 20, 2020Biophysics