Cell BiologybioRxiv
Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
K.-X. Wu, N. J. Y. Yeo, C.-Y. Ng…·C. Cheung
This study identifies hyaluronidase-1 as a key driver of glycocalyx impairment in PCV BOECs, linking it to endothelial dysfunction and proposing it as a therapeutic target.
DOI 10.1186/s12915-022-01244-z