Library Preparation and Sequencing Platform Introduce Bias in Metagenomic-Based Characterizations of Microbiomes
C. S. Poulsen, C. T. Ekstrom, F. M. Aarestrup, S. J. Pamp
This study shows that library preparation and sequencing platforms introduce systematic biases in metagenomic microbiome analysis, emphasizing the need for standardization.
bioRxiv · Jan 11, 2022Microbiology