Fatal COVID-19 and non-COVID-19 Acute Respiratory Distress Syndrome is Associated with Incomplete Alveolar Type 1 Epithelial Cell Differentiation from the Transitional State Without Fibrosis
C. Ting, M. Aspal, N. Vaishampayan, S. K. Huang, F. Wang, C. Farver, R. L. Zemans
The paper shows that in fatal ARDS, alveolar type 1 cells do not fully differentiate from transitional cells without fibrosis, leading to persistent barrier permeability and respiratory failure.
bioRxiv · Jan 12, 2021Pathology