F. Wang

Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

This study shows ATG5 and membrane atg8ylation regulate retromer function in GLUT1 trafficking, independent of canonical autophagy.

TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii

This study identifies TgATG9 as essential for autophagosome formation and chronic Toxoplasma gondii infection.

In a nutshell: pistachio genome and kernel development

This study generates a chromosome-scale pistachio genome and analyzes kernel development stages to understand molecular pathways affecting nutritional quality.

RCOR1 promotes myoblast differentiation and muscle regeneration

This study identifies RCOR1 as a positive regulator of myogenesis and skeletal muscle regeneration by interacting with LSD1 and MyoD.

Compositional Shifts and Co-occurrence Patterns of Topsoil Bacteria and Micro-Eukaryotes Across a Permafrost Thaw Gradient in Alpine Meadows of the Qilian Mountains, China

This study examines how permafrost thaw affects bacterial and micro-eukaryotic communities in alpine meadows, finding distinct responses in diversity and co-occurrence patterns.

Multi-layered apoplastic barrier underlying the ability of Na+ exclusion in Vigna marina

This study identifies a multi-layered apoplastic barrier in Vigna marina that restricts Na+ transport to shoots while allowing essential ion transport, contributing to its salt tolerance.

Identification of Glucosidase II that regulates STIM1 activation dynamics

This study identifies glucosidase II as a regulator of STIM1 activation dynamics by modulating Ca2+ binding affinity and influencing store-operated Ca2+ entry.

Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

Coral long-term recovery after bleaching: implications for sexual reproduction and physiology.

This study examines long-term effects of coral bleaching on reproduction and physiology of Montipora capitata, finding distinct transcriptomic responses and reproductive impacts between bleached and non-bleached colonies.

Diurnal regulation of SOS Pathway and Sodium Excretion Underlying Salinity Tolerance of Vigna marina

This study identifies diurnal regulation of the SOS pathway and sodium excretion mechanisms in Vigna marina, revealing a QTL region with structural rearrangements and cis-regulatory motifs linked to salt tolerance.

Structural diversity and clustering of bacterial flagellar outer domains

The paper analyzes flagellar outer domains in bacterial species, revealing structural diversity and identifying new clusters of flagellin structures.

Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

Knockout mutations of Nicotiana benthamiana defenses reveal the relative importance of acylsugars, nicotine, and a serine protease inhibitor in a natural setting

The paper evaluates the defensive roles of nicotine, acylsugars, and a serine protease inhibitor in Nicotiana benthamiana by comparing plant performance in natural and controlled settings.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

Human lymphoid-neutrophil/monocyte restriction co-ordinately activates increased proliferation despite parallel heterogeneity in transcriptional changes

The paper identifies shared proliferation acceleration and heterogeneous transcriptional changes during B-lymphoid and neutrophil/monocyte lineage restriction from CD34+ cord blood cells.

Romer-EPTI: rotating-view motion-robust super-resolution EPTI for SNR-efficient distortion-free in-vivo mesoscale dMRI and microstructure imaging

This paper introduces Romer-EPTI, a novel dMRI technique that improves SNR, motion robustness, and image quality for in-vivo mesoscale imaging.

Single-shot Echo Planar Time-resolved Imaging for multi-echo functional MRI and distortion-free diffusion imaging

This paper introduces single-shot Echo Planar Time-resolved Imaging (ss-EPTI) to improve motion robustness, temporal resolution, and SNR efficiency in dynamic imaging applications.

Self-amplifying ROS-sensitive SN38 Dimeric Prodrug nanoparticles for Combined Chemotherapy and Ferroptosis in Cancer Treatment

This paper develops SN38-CA@FC NPs, a ROS-sensitive dimeric prodrug nanoparticle that combines chemotherapy and ferroptosis to treat cancer, showing potent antitumor activity in cell lines and mouse models.

Genome and tissue-specific transcriptome of the tropical milkweed (Asclepias curassavica)

This study presents the genome and transcriptome of Asclepias curassavica, revealing tissue-specific gene expression and cardiac glycoside biosynthesis-related genes.

Rim4 is a Meiotic Thermal Sensor and Drives Biogenesis of Stress Granules

This paper identifies Rim4 as a meiotic thermal sensor that forms reversible condensates triggered by heat, promoting stress granule assembly and protecting meiotic processes from thermal stress.

Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

A precise balance of TETRASPANIN1/TORNADO2 activity is required for vascular proliferation and ground tissue patterning in Arabidopsis

This study identifies TETRASPANIN1/TORNADO2 as a regulator of vascular proliferation and ground tissue patterning in Arabidopsis through transcriptomic analysis and mutant characterization.

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

This study determines the cryo-EM structure of the EROS-NOX2-p22phox complex, revealing how EROS binds to NOX2 and regulates its activation.

Novel laminarin-binding CBMs in multimodular proteins of marine Bacteroidota feature prominently in phytoplankton blooms

The paper identifies and characterizes novel laminarin-binding CBMs in marine Bacteroidota, showing their prevalence in phytoplankton blooms.

Hsa_circ_0005397 could promote hepatocellular carcinoma progression and metastasis through EIF4A3

This study identifies hsa_circ_0005397 as a promoter of hepatocellular carcinoma progression and metastasis via EIF4A3, showing its diagnostic and prognostic significance.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.