Computational and experimental evidence to the permeability of withanolides across the normal cell membrane
R. Wadhwa, N. S. Yadav, S. P. Katiyar, T. Yaguchi, C. Lee, H. Ahn, C.-O. Yun, S. C. Kaul, D. Sundar
This study uses computational simulations and experiments to show that withaferin-A, but not withanone, can cross cell membranes due to differences in their molecular interactions with the membrane.
bioRxiv · Oct 11, 2019 · PreprintBiophysics