Origins Anywhere and Everywhere: Genome replication requires cooperative activation of thousands of origins in each cell
Linh Thuy Nguyen, Caitlyn Jean-Baptiste, Julie Gabetto, Bishal Acharya, Daniele Raimondi, Marta Radman‐Livaja
The paper shows that genome replication in yeast requires the cooperative activation of thousands of origins across the genome, driven by ORC binding and 3D chromosome folding.
bioRxiv · Aug 20, 2026 · PreprintGenomics