Deep mutational scanning identifies variants of Cas1 and Cas2 that increase spacer acquisition in type II-A CRISPR-Cas systems
Raphael Hofmann, Calvin Herman, Charlie Y. Mo, Jacob Mathai, Luciano A. Marraffini
The paper uses deep mutational scanning to identify Cas1 and Cas2 variants that enhance spacer acquisition in CRISPR-Cas systems, improving immunity against phage infection.
Nature Communications · Jul 1, 2025Peer-reviewedMicrobiology