Charlie Y. Mo

The paper shows RNA polymerase backtracking promotes type III-A CRISPR DNA targeting by inhibiting GreA anti-backtracking factors, which suppress Cas10-Csm activity.

This study shows that Staphylococcus epidermidis rapidly deletes anti-MGE defense regions, increasing HGT, with environmental conditions influencing the balance between defense and genetic novelty.

This study shows that phage infection reduces β-lactam resistance and virulence in MRSA by altering gene expression and genetic profiles.

The paper uses deep mutational scanning to identify Cas1 and Cas2 variants that enhance spacer acquisition in CRISPR-Cas systems, improving immunity against phage infection.

This study introduces PhageMaP, a high-throughput method to assess gene essentiality in bacteriophages across diverse hosts and uses it to engineer synthetic phages with enhanced infectivity.