Long-chain polyphosphates impair SARS-CoV-2 infection and replication: a route for therapy in man
Veronica Ferrucci, Dae-Young Kong, Fatemeh Asadzadeh, Laura Marrone, Angelo Sabato Boccia, Roberto Siciliano, Giuseppina Criscuolo, Camilla Anastasio, Fabrizio Quarantelli, Marika Comegna, Ida Pisano, Margherita Passariello, Ilaria Iacobucci, Rosa Della Monica, Barbara Izzo, , Massimo Zollo
The paper investigates the anti-viral effects of long-chain polyphosphates (PolyPs) against SARS-CoV-2, showing they impair infection and replication by interacting with ACE2 and RdRp.
Science Signaling · Jul 6, 2021Peer-reviewedGenetics