TLN468 changes the pattern of tRNA used to readthrough premature termination codons in CFTR
Sabrina Karri, David Cornu, Claudia Serot, Lynda Biri, Aurélie Hatton, Elise Dréanot, Camille Rullaud, Iwona Maria Pranke, Isabelle Sermet‐Gaudelus, Alexandre Hinzpeter, Laure Bidou, Olivier Namy
This study shows TLN468 promotes specific amino acid incorporation at CFTR PTCs, leading to functional CFTR variants, while gentamicin does not significantly alter amino acid proportions.
Journal of Cystic Fibrosis · Aug 3, 2024Peer-reviewedMolecular Biology