Genome-wide association, Mendelian Randomization and polygenic risk score studies converge on a role of beta-amyloid and APOE locus in Parkinson disease
Laura Ibáñez, Jorge Alberto Bahena, Chengran Yang, Umber Dube, Fabiana Farias, John Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin, Nigel J. Cairns, John O’Donnell, Ignacio Álvarez, Mónica Díez-Fairén, Miquel Aguilar, , Bruno A. Benítez
The paper uses GWAS, PRS, and MR to show a genetic link between Parkinson's disease and CSF Aβ42 and APOE locus.
Acta Neuropathologica Communications · Nov 19, 2020Peer-reviewedGenetic & Genomic Medicine