Carolann McNicoll

Tau-related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is gradually modulated by β amyloid

The paper investigates the relationship between tau PET, glucose metabolism, and beta-amyloid in MCI, finding that tau scores are strongly correlated with reduced glucose metabolism independently of APOE ε4 and modulated by beta-amyloid.

Spatial association between distributed β-amyloid and tau varies with cognition

The paper introduces CDCA to analyze spatial associations between β-amyloid and tau in AD, finding cognition-dependent patterns not captured by traditional metrics.