Félix Carbonell

This paper introduces a method to estimate PET image spatial resolution without phantoms, validated on clinical and ADNI datasets, showing consistent results across tracers and scanners.

The paper examines sex-specific and APOE4-related associations between cardiometabolic risk factors and white matter microstructure in individuals with a family history of Alzheimer's disease.

The paper examines the relationship between white matter microstructure and cognitive-motor behavior using multivariate analysis, revealing distinct and overlapping associations across brain regions.

The paper introduces MVComp, a tool for computing Mahalanobis distance in brain MRI data to assess deviations from reference groups and provide insights into white matter microstructure.

The paper investigates the relationship between tau PET, glucose metabolism, and beta-amyloid in MCI, finding that tau scores are strongly correlated with reduced glucose metabolism independently of APOE ε4 and modulated by beta-amyloid.

The paper introduces CDCA to analyze spatial associations between β-amyloid and tau in AD, finding cognition-dependent patterns not captured by traditional metrics.

The paper uses computational models to identify transcriptomic signatures linked to Aβ and tau-induced neuronal dysfunction in Alzheimer's disease, highlighting immune and inflammatory processes.

The paper develops a personalized brain activity model integrating functional MRI, Aβ, and tau-PET to reveal synergistic effects of Aβ and tau on cognitive impairment and neuronal excitability in Alzheimer's disease.