Elucidation of Amyloid-Beta's Gambit in Oligomerisation:Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, low molecular weight Aβ oligomers that impair synaptic plasticity.
Beatriz Gil, Jamie L. Rose, Davide Demurtas, Gian‐Filippo Mancini, Jessica Sordet‐Dessimoz, Vincenzo Sorrentino, Nikita Rudinskiy, Matthew P. Frosch, Bradley T. Hyman, Marc Moniatte, Tara L. Spires‐Jones, Caroline E. Herron, Adrien W. Schmid
This study identifies truncated Aβ fragments that form SDS-stable, low molecular weight oligomers impairing synaptic plasticity and evading conventional antibodies.
bioRxiv · Dec 4, 2022 · PreprintNeuroscience