A Commensal-Derived Lipoteichoic Acid Engages an Inducible Neuronal PD-1 Checkpoint to Suppress Inflammatory Pain
Zhiqiang Liu, Yen-Hsin Cheng, Catherine V. Osborn, Marco Martina, Anthony J. Schaeffer, Praveen Thumbikat
This study identifies a commensal-derived lipoteichoic acid that activates a neuronal PD-1 checkpoint to suppress inflammatory pain through TLR2/6 signaling.
bioRxiv · Apr 9, 2026 · PreprintNeuroscience