Anthony J. Schaeffer

This study identifies microglial TLR4 as a critical mediator of post-UTI chronic pelvic pain in mice through functional and transcriptomic analyses.

This study identifies a commensal-derived lipoteichoic acid that activates a neuronal PD-1 checkpoint to suppress inflammatory pain through TLR2/6 signaling.

This study shows AOAH deficiency causes gut dysbiosis and pelvic pain in mice, suggesting AOAH regulates microbiota and that microbiota may be a therapeutic target for IC/BPS.

This study shows that AOAH deficiency causes gut dysbiosis and pelvic pain, which can be mitigated by knocking out AhR and PPARγ in CRF-expressing cells, revealing a novel mechanism and therapeutic targets.

This study shows AOAH and TLR4 regulate microglial activation and pelvic pain in IC/BPS by linking gut microbiota to CNS immune responses.