Next generation digital PCR: high dynamic range single molecule DNA counting via ultra-partitioning
Eleen Y. Shum, Janice H. Lai, Sixing Li, Haeun G. Lee, Jesse Soliman, Vedant K. Raol, Cavina K. Lee, Stephen P. A. Fodor, H. Christina Fan
This paper introduces Ultra-dPCR, a next generation digital PCR system that enables single-molecule DNA counting with a 6-log dynamic range, demonstrating its potential for non-invasive prenatal testing.
bioRxiv · Aug 1, 2022 · PreprintGenomics