The host environment rather than biofilm growth activates stress responses and conveys ciprofloxacin tolerance in Staphylococcus aureus
Maiken Engelbrecht Petersen, Amanda Batoul Khamas, Cecilie Aaberg Meltofte, Freja Cecilie Mikkelsen, Emma Iben Boskov Hundevadt, Marie Eline Hoppe, Thomas Keith Wood, Rikke Louise Meyer
This study shows that the host environment, not biofilm growth, activates stress responses in Staphylococcus aureus and leads to ciprofloxacin tolerance at the single-cell level.
bioRxiv · Aug 7, 2025 · PreprintMicrobiology