The Immune Landscape of Tumor-Associated Macrophage Reprogramming
Florent Duval, João Lourenço, Mehdi Hicham, Gaël Boivin, Alan Guichard, Celine Wyser-Rmili, Nadine Fournier, Michele De Palma, Nahal Mansouri
This study uses single-cell RNA sequencing to show that Dicer1 deficiency in macrophages reprograms tumor-associated macrophages to an immunostimulatory state, enhancing antiangiogenic immunotherapy response in mouse models.
bioRxiv · Sep 25, 2024 · PreprintCancer Biology