Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in Heart Failure with Preserved Ejection Fraction
Hangyul Song, Chahyun Yun, Yun Ju Choi, Wooju Jeong, Yumin Kim, Jaeyoung Kim, Ju Yeon Lee, Dongryeol Ryu, Sang-Wook Park, Chang‐Myung Oh
This study shows that urolithin A improves diastolic function and reduces cardiac remodeling in a HFpEF mouse model by restoring mitochondrial quality control and mitophagy.
bioRxiv · Dec 26, 2025 · PreprintMolecular Biology