Chai-1: Decoding the molecular interactions of life
Chai Discovery, Jacques Boitreaud, Jack Dent, Matt McPartlon, Joshua Meier, Vinicius Reis, Alex Rogozhnikov, Kevin Wu
Chai-1 matches AlphaFold3 on PoseBusters ligand poses (77% vs 76%), beats AlphaFold-Multimer 2.3 on low-homology interfaces, and stays competitive without MSAs on multimers and antibodies.
bioRxiv · Oct 10, 2024 · PreprintSynthetic Biology✦ In-depth digest