Tissue Reconstruction with Generative AI
Tingyang Yu, Chanakya Ekbote, Nikita Morozov, Antonio Herrera, Jiashuo Fan, Albert Dominguez Mantes, Salvatore Novello, Hilal Ahmed Lashuel, Pascal Frossard B, Stéphane d’Ascoli, Gioele La Manno, Maria Brbić
LUNA reconstructs tissue architecture from dissociated single-cell RNA-seq data using spatial priors learned from spatial transcriptomics, validating on mouse brain datasets and disease models.
bioRxiv · Feb 13, 2025 · PreprintBioinformatics