Salvatore Novello

This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.

LUNA reconstructs tissue architecture from dissociated single-cell RNA-seq data using spatial priors learned from spatial transcriptomics, validating on mouse brain datasets and disease models.

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

This paper introduces a new microfabricated neural probe that enables precise, transient-free sampling of brain extracellular fluid biomarkers in vivo and in vitro.

The paper shows that neighboring post-translational modifications affect the detection of phosphorylated alpha-synuclein at Serine 129 by existing antibodies.

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.