Non-redundant roles of the HDAC3 corepressor complex subunits SMRT and NCOR in controlling inflammatory and metabolic macrophage pathways
Astradeni Efthymiadou, Chaode Gu, Cheng Wang, Hongwei Wang, Ziyi Li, Oihane García‐Irigoyen, Rongrong Fan, Eckardt Treuter, Zhiqiang Huang
This study investigates the distinct roles of SMRT and NCOR in the HDAC3 corepressor complex, showing they differentially regulate inflammatory and metabolic pathways in macrophages through chromatin and transcriptional mechanisms.
bioRxiv · May 13, 2025 · PreprintMolecular Biology