Cheng Wang

This study identifies AEBP2 as a therapeutic target in EZH2-mutant lymphoma by showing its role in maintaining H3K27me2 levels through a PRC2.2 complex.

This study investigates the distinct roles of SMRT and NCOR in the HDAC3 corepressor complex, showing they differentially regulate inflammatory and metabolic pathways in macrophages through chromatin and transcriptional mechanisms.

The paper uses systems analysis to identify a molecular network in hypoplastic left heart syndrome, revealing novel factors and mechanisms through integration of genomic and transcriptomic data.

The paper investigates how CTCF site orientation relates to TAD structure by analyzing 4C data and spatial CTCF patterns, finding divergent sites at TAD boundaries and convergent sites within TADs.