Discovering patterns of pleiotropy in genome-wide association studies
Jianan Zhana, CHARGE ECG Working Group, Jessica van Setten, Jennifer A. Brody, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola Del Greco M, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, , Steven Ron Cummings
This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.
bioRxiv · Feb 28, 2018 · PreprintGenetics